A quantitative assay of covalently bound cephalosporin derivatives in cephalosporin-protein conjugates.
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Cephalosporin podand derivatives.
work in the synthesis of podand molecules6), the present paper describes the preparation of certain podand-type trimers of cephalosporin antibiotics (Scheme 1 ). As the central block of the target trimers the tricarboxylic acid 3 was employed, which was obtained by the alkylation of phloroglucinol (1) with methyl bromoacetate and subsequent alkaline hydrolysis. The tert-butyl esters of 7-aminoc...
متن کاملPreparation of 7-epi-cephalosporin derivatives.
position 6,1-4) the preparation of 7-epi-aminocephalosporanic 'acid (7a-ACA) has thus far not been reported. Some 7-epi-cephalosporins have been prepared by base-catalyzed epimerization of cephalosporin sulfoxidesu or acidcatalyzed ring expansion of 6-epi-penicillins.e) Both procedures, however, are not convenient for the preparation of 7-epi-cephalosporin derivatives. We wish to report the direct
متن کاملCerebrospinal Fluid Concentrations of Penicillin and Cephalosporin Derivatives
Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose ...
متن کاملSusceptibility of Bordetella pertussis to cephalosporin derivatives and imipenem.
The in vitro activities of 16 cephalosporin derivatives and imipenem against 60 strains of Bordetella pertussis were examined. Cefoperazone, imipenem, and ceftriaxone were the most active, with MICs that inhibited 90% of the strains of 0.006, 0.05, and 0.1 microgram/ml, respectively. Cephalexin, cephradine, and cefsulodin were the least active, with MICs of 25 to 125 micrograms/ml. The remainde...
متن کاملBiosynthesis of Cephalosporin
OTT, J. L. (Eli Lilly and Co., Indianapolis, Ind.), C. W. GODZESKI, D. PAVEY, J. D. FARRAN, AND D. R. HORTON. Biosynthesis of cephalosporin C. I. Factors affecting the fermentation. Appl. Microbiol. 10:515-523. 1962.-A series of complex and synthetic media have been developed that are suitable for the production of cephalosporin C and cephalosporin N by a mutant strain of Cephalosporium (C.M.I....
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1976
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.29.665